| Function | Plays a role in the organization of the actin cytoskeleton. May function as ATP-binding component of the Arp2/3 complex which is involved in regulation of actin polymerization and together with an activating nucleation-promoting factor (NPF) mediates the formation of branched actin networks. May decrease the metastatic potential of tumors. PubMed UniProt |
| Phenotypes |
abnormal nucleus shape [CMPO:0000157];
binuclear cell [CMPO:0000213];
MitoCheck |
| Diseases | |
| Localization |
cell projection [GO:0042995];
cytoplasm [GO:0005737];
cytoskeleton [GO:0005856];
UniProt |
| Tissues/Cell Types |
pancreas [BTO:0000988];
skeletal muscle [BTO:0001103];
UniProt |
| Protein and Genetic Interactions | BioGRID |
| CRISPR Screens | BioGRID ORCS CRISPR Screen Phenotypes |
| Isoforms |
3 isoform(s):
Isoform 1;
Isoform 2;
Isoform 3;
UniProt |
| Orthologs | NCBI orthologs |
| Notes |
